Drug Points: Zidovudine related arthropathy

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comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

15 صفحه اول

[Drug induced arthropathy and necrosis of the femoral head].

Necrosis of the femoral head has long been known to occur after fractures and dislocations of the hip (Phemister 1934), in caisson disease (Kahlstrom, Burton and Phemister 1939), Gaucher’s disease (Schein and Arkin 1942), sickle-cell disease (Carroll and Evans 1949: Moseley and Manly 1953) and after ionising radiation (Vaughan 1956). It has generally been assumed that some degree of vascular in...

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Zidovudine.

Zidovudine was the first agent approved for treatment of HIV disease, and since its widespread availability in 1987, the pharmacokinetic disposition and clinical effects of ZDV have been extensively evaluated. In addition to its utility as a component of a multidrug combination regimen for the treatment of adult and pediatric HIV-1 infection, it is the only agent approved by the FDA for the pre...

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Dialysis Related Amyloid Arthropathy on 18FDG PET-CT

A 60 year-old male patient with end stage kidney disease secondary to Alport syndrome presented with worsening swelling and pain in both shoulders. He had been on regular haemodialysis for 20 years, having had two failed renal transplants previously and had renal amyloidosis confirmed on renal biopsy. Radiographs of the shoulders showed evidence of an erosive arthropathy affecting the glenohume...

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Amyloid, advanced glycation end products, and dialysis related arthropathy.

Dialysis associated arthropathy (DRA) is a syndrome peculiar to long term dialysis patients. It includes large and small joint symptoms, pathological fractures through bony cysts and an axial spondyloarthropathy, and is closely associated with carpal tunnel syndrome. It is characterised by deposition of â2 microglobulin (â2M) as an amyloid protein. This was first linked to the osteoarticular sy...

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ژورنال

عنوان ژورنال: BMJ

سال: 1994

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.309.6947.97